Role of cerebral hypoperfusion in multiple sclerosis (ROCHIMS): study protocol for a proof-of-concept randomized controlled trial with bosentan

BACKGROUND: Axonal degeneration is related to long-term disability in patients with multiple sclerosis (MS). The underlying mechanism remains ill understood but appears to involve axonal energetic dysfunction. A globally impaired cerebral blood flow (CBF) has been observed in the normal-appearing wh...

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Bibliographische Detailangaben
Veröffentlicht in:Trials
Hauptverfasser: Hostenbach, Stéphanie, Pauwels, Ayla, Michiels, Veronique, Raeymaekers, Hubert, Van Binst, Anne-Marie, Van Merhaeghen-Wieleman, Annick, Van Schuerbeek, Peter, De Keyser, Jacques, D’Haeseleer, Miguel
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Study Protocol
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416892/
https://ncbi.nlm.nih.gov/pubmed/30871594
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13063-019-3252-4
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