Exome, transcriptome and miRNA analysis don’t reveal any molecular markers of TKI efficacy in primary CML patients

BACKGROUND: Approximately 5–20% of chronic myeloid leukemia (CML) patients demonstrate primary resistance or intolerance to imatinib. None of the existing predictive scores gives a good prognosis of TKI efficacy. Gene polymorphisms, expression and microRNAs are known to be involved in the pathogenes...

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Pubblicato in:BMC Med Genomics
Autori principali: Lavrov, Alexander V., Chelysheva, Ekaterina Yu., Adilgereeva, Elmira P., Shukhov, Oleg A., Smirnikhina, Svetlana A., Kochergin-Nikitsky, Konstantin S., Yakushina, Valentina D., Tsaur, Grigory A., Mordanov, Sergey V., Turkina, Anna G., Kutsev, Sergey I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416830/
https://ncbi.nlm.nih.gov/pubmed/30871622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-019-0481-z
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