mTOR inhibitor and bone-targeted drugs break the vicious cycle between clear-cell renal carcinoma and osteoclasts in an in vitro co-culture model

The skeleton is one of the most common sites of metastatic spread from advanced clear-cell renal carcinoma (ccRCC). Most of the bone lesions observed in RCC patients are classified as osteolytic, causing severe pain and morbidity due to pathological bone destruction. Nowadays, it is well known that...

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Publicado en:J Bone Oncol
Autores principales: Spadazzi, Chiara, Recine, Federica, Mercatali, Laura, Miserocchi, Giacomo, Liverani, Chiara, De Vita, Alessandro, Bongiovanni, Alberto, Fausti, Valentina, Ibrahim, Toni
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416775/
https://ncbi.nlm.nih.gov/pubmed/30911462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbo.2019.100227
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