The Circadian Clock Protein CRY1 Is a Negative Regulator of HIF-1α

The circadian clock and the hypoxia-signaling pathway are regulated by an integrated interplay of positive and negative feedback limbs that incorporate energy homeostasis and carcinogenesis. We show that the negative circadian regulator CRY1 is also a negative regulator of hypoxia-inducible factor (...

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Detalhes bibliográficos
Publicado no:iScience
Main Authors: Dimova, Elitsa Y., Jakupovic, Mirza, Kubaichuk, Kateryna, Mennerich, Daniela, Chi, Tabughang Franklin, Tamanini, Filippo, Oklejewicz, Małgorzata, Hänig, Jens, Byts, Nadiya, Mäkelä, Kari A., Herzig, Karl-Heinz, Koivunen, Peppi, Chaves, Ines, van der Horst, Gijsbertus, Kietzmann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416729/
https://ncbi.nlm.nih.gov/pubmed/30875610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.02.027
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