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The 5-formyltetrahydrofolate futile cycle reduces pathway stochasticity in an extended hybrid-stochastic model of folate-mediated one-carbon metabolism

In folate-mediated one-carbon metabolism (FOCM), 5-formyltetrahydrofolate (5fTHF), a one-carbon substituted tetrahydrofolate (THF) vitamer, acts as an intracellular storage form of folate and as an inhibitor of the folate-dependent enzymes phosphoribosylaminoimidazolecarboxamide formyltransferase (A...

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Podrobná bibliografie
Vydáno v:Sci Rep
Hlavní autoři: Misselbeck, Karla, Marchetti, Luca, Priami, Corrado, Stover, Patrick J., Field, Martha S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416297/
https://ncbi.nlm.nih.gov/pubmed/30867454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40230-4
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