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NAP (davunetide) preferential interaction with dynamic 3-repeat Tau explains differential protection in selected tauopathies

The microtubule (MT) associated protein Tau is instrumental for the regulation of MT assembly and dynamic instability, orchestrating MT-dependent cellular processes. Aberration in Tau post-translational modifications ratio deviation of spliced Tau isoforms 3 or 4 MT binding repeats (3R/4R) have been...

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Vydáno v:PLoS One
Hlavní autoři: Ivashko-Pachima, Yanina, Maor-Nof, Maya, Gozes, Illana
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415897/
https://ncbi.nlm.nih.gov/pubmed/30865715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0213666
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