Pivotal role of inter-organ aspartate metabolism for treatment of mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency, based on the mouse model

Previous studies using citrin/mitochondrial glycerol-3-phosphate (G3P) dehydrogenase (mGPD) double-knockout mice have demonstrated that increased dietary protein reduces the extent of carbohydrate-induced hyperammonemia observed in these mice. This study aimed to further elucidate the mechanisms of...

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Pubblicato in:Sci Rep
Autori principali: Saheki, Takeyori, Moriyama, Mitsuaki, Kuroda, Eishi, Funahashi, Aki, Yasuda, Izumi, Setogawa, Yoshiko, Gao, Qinghua, Ushikai, Miharu, Furuie, Sumie, Yamamura, Ken-ichi, Takano, Katsura, Nakamura, Yoichi, Eto, Kazuhiro, Kadowaki, Takashi, Sinasac, David S., Furukawa, Tatsuhiko, Horiuchi, Masahisa, Tai, Yen How
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414645/
https://ncbi.nlm.nih.gov/pubmed/30862943
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39627-y
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