Comprehensive Identification of Protein Disulfide Bonds with Pepsin/Trypsin Digestion, Orbitrap HCD and Spectrum Identification Machine

Disulfide bonds (SS) are post-translational modifications important for the proper folding and stabilization of many cellular proteins with therapeutic uses, including antibodies and other biologics. With budding advances of biologics and biosimilars, there is a mounting need for a robust method for...

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Pubblicato in:J Proteomics
Autori principali: Cui, Chuanlong, Liu, Tong, Chen, Tong, Lu, Johanna, Casaren, Ian, Lima, Diogo Borges, Carvalho, Paulo Costa, Beuve, Annie, Li, Hong
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414265/
https://ncbi.nlm.nih.gov/pubmed/30557666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jprot.2018.12.010
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