Performance of DAXX Immunohistochemistry as a Screen for DAXX Mutations in Pancreatic Neuroendocrine Tumors

OBJECTIVES: DAXX immunohistochemistry (IHC) is often used as a surrogate for sequencing. We aimed to elucidate the sensitivity of IHC for DAXX mutation. METHODS: All pancreatic neuroendocrine tumors (PanNETs) with DAXX mutations detected by sequencing and a subset of DAXX wild type PanNETs were anal...

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Veröffentlicht in:Pancreas
Hauptverfasser: Hechtman, Jaclyn F., Klimstra, David S., Nanjangud, Gouri, Frosina, Denise, Shia, Jinru, Jungbluth, Achim A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414083/
https://ncbi.nlm.nih.gov/pubmed/30747827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MPA.0000000000001256
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