O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype

BACKGROUND: Changes in glycosylation are known to play critical roles during gastric carcinogenesis. Expression of truncated O-glycans, such as the Sialyl-Tn (STn) antigen, is a common feature shared by many cancers and is associated with cancer aggressiveness and poor-prognosis. METHODS: Glycoengin...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Freitas, Daniela, Campos, Diana, Gomes, Joana, Pinto, Filipe, Macedo, Joana A., Matos, Rita, Mereiter, Stefan, Pinto, Marta T., Polónia, António, Gartner, Fátima, Magalhães, Ana, Reis, Celso A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
Schlagworte:
Research paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413340/
https://ncbi.nlm.nih.gov/pubmed/30662000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.017
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