Peroxisome Proliferator-Activated Receptor-γ Knockdown Impairs Bone Morphogenetic Protein-2–Induced Critical-Size Bone Defect Repair

The Food and Drug Administration–approved clinical dose (1.5 mg/mL) of bone morphogenetic protein-2 (BMP2) has been reported to induce significant adverse effects, including cyst-like adipose-infiltrated abnormal bone formation. These undesirable complications occur because of increased adipogenesis...

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Udgivet i:Am J Pathol
Main Authors: Wang, Chenchao, Tanjaya, Justine, Shen, Jia, Lee, Soonchul, Bisht, Bharti, Pan, Hsin Chuan, Pang, Shen, Zhang, Yulong, Berthiaume, Emily A., Chen, Eric, Da Lio, Andrew L., Zhang, Xinli, Ting, Kang, Guo, Shu, Soo, Chia
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Investigative Pathology 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412314/
https://ncbi.nlm.nih.gov/pubmed/30593824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2018.11.019
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