S1P/S1PR3 axis promotes aerobic glycolysis by YAP/c-MYC/PGAM1 axis in osteosarcoma

BACKGROUND: Osteosarcoma (OS) is a malignant tumor mainly occurring in young people. Due to the limited effective therapeutic strategies, OS patients cannot achieve further survival improvement. G-protein-coupled receptors (GPCRs) constitute the largest family of cell membrane receptors and conseque...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Shen, Yifei, Zhao, Shujie, Wang, Shenyu, Pan, Xiaohui, Zhang, Yunkun, Xu, Jingwen, Jiang, Yuqing, Li, Haibo, Zhang, Qiang, Gao, Jianbo, Yang, Qin, Zhou, Yang, Jiang, Shuheng, Yang, Huilin, Zhang, Zhigang, Zhang, Rong, Li, Jun, Zhou, Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412077/
https://ncbi.nlm.nih.gov/pubmed/30587459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.038
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