Synthesis, Characterisation and In Vitro Permeation, Dissolution and Cytotoxic Evaluation of Ruthenium(II)-Liganded Sulpiride and Amino Alcohol

Sulpiride (SPR) is a selective antagonist of central dopamine receptors but has limited clinical use due to its poor pharmacokinetics. The aim of this study was to investigate how metal ligation to SPR may improve its solubility, intestinal permeability and prolong its half-life. The synthesis and c...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: M’bitsi-Ibouily, Gretta C., Marimuthu, Thashree, Kumar, Pradeep, Choonara, Yahya E., du Toit, Lisa C., Pradeep, Priyamvada, Modi, Girish, Pillay, Viness
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2019
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412051/
https://ncbi.nlm.nih.gov/pubmed/30858469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40538-1
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