DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have demonstrated the fundamental contribution of DNA ligase 4-dependent classical non-homologous end-joining to long-range inter-chromosomal telomere fusions. In c...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Liddiard, Kate, Ruis, Brian, Kan, Yinan, Cleal, Kez, Ashelford, Kevin E, Hendrickson, Eric A, Baird, Duncan M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2019
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411840/
https://ncbi.nlm.nih.gov/pubmed/30590694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1279
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