DNA Ligase 1 is an essential mediator of sister chromatid telomere fusions in G2 cell cycle phase

Fusion of critically short or damaged telomeres is associated with the genomic rearrangements that support malignant transformation. We have demonstrated the fundamental contribution of DNA ligase 4-dependent classical non-homologous end-joining to long-range inter-chromosomal telomere fusions. In c...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Liddiard, Kate, Ruis, Brian, Kan, Yinan, Cleal, Kez, Ashelford, Kevin E, Hendrickson, Eric A, Baird, Duncan M
Format: Artigo
Language:Inglês
Published: Oxford University Press 2019
Subjects:
Genome Integrity, Repair and Replication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411840/
https://ncbi.nlm.nih.gov/pubmed/30590694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1279
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