Trimetazidine Attenuates Exhaustive Exercise-Induced Myocardial Injury in Rats via Regulation of the Nrf2/NF-κB Signaling Pathway

Exhausted exercise has been reported to cause the damage of myocardial structure and function in terms of cardiomyocyte apoptosis, oxidative stress, and energy metabolism disturbance. Trimetazidine (TMZ), as an anti-ischemic agent, has been approved to be effective in promoting myocardial energy met...

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Publicat a:Front Pharmacol
Autors principals: Zhang, Hongming, Liu, Moyan, Zhang, Yuyan, Li, Xiaoyan
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411712/
https://ncbi.nlm.nih.gov/pubmed/30890937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2019.00175
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