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Single quantum dot imaging reveals PKCβ-dependent alterations in membrane diffusion and clustering of an ADHD/autism/bipolar disorder-associated dopamine transporter variant

The dopamine transporter (DAT) is a transmembrane protein that terminates dopamine signaling in the brain by driving rapid dopamine reuptake into presynaptic nerve terminals. Several lines of evidence indicate that DAT dysfunction is linked to neuropsychiatric disorders such as attention-deficit/hyp...

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Veröffentlicht in:ACS Chem Neurosci
Hauptverfasser: Tha, Lucas B., Tomlinson, Ian D., Quinlan, Meagan, Kovtun, Oleg, Blakely, Randy D., Rosenthal, Sandra J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411462/
https://ncbi.nlm.nih.gov/pubmed/30153408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschemneuro.8b00350
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