MuSK myasthenia gravis monoclonal antibodies: Valency dictates pathogenicity

OBJECTIVE: To isolate and characterize muscle-specific kinase (MuSK) monoclonal antibodies from patients with MuSK myasthenia gravis (MG) on a genetic and functional level. METHODS: We generated recombinant MuSK antibodies from patient-derived clonal MuSK-specific B cells and produced monovalent Fab...

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Pubblicato in:Neurol Neuroimmunol Neuroinflamm
Autori principali: Huijbers, Maartje G., Vergoossen, Dana L., Fillié-Grijpma, Yvonne E., van Es, Inge E., Koning, Marvyn T., Slot, Linda M., Veelken, Hendrik, Plomp, Jaap J., van der Maarel, Silvère M., Verschuuren, Jan J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410930/
https://ncbi.nlm.nih.gov/pubmed/30882021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/NXI.0000000000000547
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