Role of UCHL1 in axonal injury and functional recovery after cerebral ischemia

Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique brain-specific deubiquitinating enzyme. Mutations in and aberrant function of UCHL1 have been linked to many neurological disorders. UCHL1 activity protects neurons from hypoxic injury, and binding of stroke-induced reactive lipid species to the...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Liu, Hao, Povysheva, Nadya, Rose, Marie E., Mi, Zhiping, Banton, Joseph S., Li, Wenjin, Chen, Fenghua, Reay, Daniel P., Barrionuevo, Germán, Zhang, Feng, Graham, Steven H.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410860/
https://ncbi.nlm.nih.gov/pubmed/30760601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821282116
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