Mutation Spectrum in TPO Gene of Bangladeshi Patients with Thyroid Dyshormonogenesis and Analysis of the Effects of Different Mutations on the Structural Features and Functions of TPO Protein through In Silico Approach

Although thyroid dyshormonogenesis (TDH) accounts for 10-20% of congenital hypothyroidism (CH), the molecular etiology of TDH is unknown in Bangladesh. Thyroid peroxidase (TPO) is most frequently associated with TDH and the present study investigated the spectrum of TPO mutations in Bangladeshi pati...

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Gepubliceerd in:Biomed Res Int
Hoofdauteurs: Begum, Mst. Noorjahan, Islam, Md Tarikul, Hossain, Shekh Rezwan, Bhuyan, Golam Sarower, Halim, Mohammad A., Shahriar, Imrul, Sarker, Suprovath Kumar, Haque, Shahinur, Konika, Tasnia Kawsar, Islam, Md. Sazzadul, Rahat, Asifuzzaman, Qadri, Syeda Kashfi, Sultana, Rosy, Begum, Suraiya, Sultana, Sadia, Saha, Narayan, Hasan, Mizanul, Hasanat, M. A., Banu, Hurjahan, Shekhar, Hossain Uddin, Chowdhury, Emran Kabir, Sajib, Abu A., Islam, Abul B. M. M. K., Qadri, Syed Saleheen, Qadri, Firdausi, Akhteruzzaman, Sharif, Mannoor, Kaiissar
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Hindawi 2019
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409061/
https://ncbi.nlm.nih.gov/pubmed/30915365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/9218903
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