The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Whether tobacco carcinogens enable exposed cells immune escape resulting in carcinogenesis, and why patients who smoke respond better to immunotherapies than non-smokers, remains poorly understood. Here we report that cigarette smoke and the carcinogen benzo(a)pyrene (BaP) induce PD-L1 expression on...

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Gepubliceerd in:Nat Commun
Hoofdauteurs: Wang, Gui-Zhen, Zhang, Li, Zhao, Xin-Chun, Gao, San-Hui, Qu, Li-Wei, Yu, Hong, Fang, Wen-Feng, Zhou, Yong-Chun, Liang, Fan, Zhang, Chen, Huang, Yun-Chao, Liu, Zhihua, Fu, Yang-Xin, Zhou, Guang-Biao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408580/
https://ncbi.nlm.nih.gov/pubmed/30850589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08887-7
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