Deciphering the complex role of thrombospondin-1 in glioblastoma development

We undertook a systematic study focused on the matricellular protein Thrombospondin-1 (THBS1) to uncover molecular mechanisms underlying the role of THBS1 in glioblastoma (GBM) development. THBS1 was found to be increased with glioma grades. Mechanistically, we show that the TGFβ canonical pathway t...

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Publicat a:Nat Commun
Autors principals: Daubon, Thomas, Léon, Céline, Clarke, Kim, Andrique, Laetitia, Salabert, Laura, Darbo, Elodie, Pineau, Raphael, Guérit, Sylvaine, Maitre, Marlène, Dedieu, Stéphane, Jeanne, Albin, Bailly, Sabine, Feige, Jean-Jacques, Miletic, Hrvoje, Rossi, Marco, Bello, Lorenzo, Falciani, Francesco, Bjerkvig, Rolf, Bikfalvi, Andréas
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408502/
https://ncbi.nlm.nih.gov/pubmed/30850588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08480-y
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