Magnetically guided non-invasive CRISPR-Cas9/gRNA delivery across blood-brain barrier to eradicate latent HIV-1 infection

CRISPR-Cas9/gRNA exhibits therapeutic efficacy against latent human immunodeficiency virus (HIV) genome but the delivery of this therapeutic cargo to the brain remains as a challenge. In this research, for the first time, we demonstrated magnetically guided non-invasive delivery of a nano-formulatio...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kaushik, Ajeet, Yndart, Adriana, Atluri, Venkata, Tiwari, Sneham, Tomitaka, Asahi, Gupta, Purnima, Jayant, Rahul Dev, Alvarez-Carbonell, David, Khalili, Kamel, Nair, Madhavan
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408460/
https://ncbi.nlm.nih.gov/pubmed/30850620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40222-4
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