EGFR-Aurka Signaling Rescues Polarity and Regeneration Defects in Dystrophin-Deficient Muscle Stem Cells by Increasing Asymmetric Divisions

Loss of dystrophin expression in Duchenne Muscular Dystrophy (DMD) causes progressive degeneration of skeletal muscle, which is exacerbated by reduced self-renewing asymmetric divisions of muscle satellite cells. This in turn impacts production of myogenic precursors and impairs regeneration, and su...

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Publicat a:Cell Stem Cell
Autors principals: Wang, Yu Xin, Feige, Peter, Brun, Caroline E., Hekmatnejad, Bahareh, Dumont, Nicolas A., Renaud, Jean-Marc, Faulkes, Sharlene, Guindon, Dan, Rudnicki, Michael A.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408300/
https://ncbi.nlm.nih.gov/pubmed/30713094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2019.01.002
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