Ultra-small micelles based on polyoxyl 15 hydroxystearate for ocular delivery of myricetin: optimization, in vitro, and in vivo evaluation

The aim was to develop a nanocarrier based on polyoxyl 15 hydroxystearate (Kolliphor® HS15, HS15) micelles for the solubility, stability, and ocular delivery of myricetin (Myr). An optimized ratio of HS15 and Myr was prepared to fabricate HS15-Myr micelle ophthalmic solution. Myr-encapsulating HS15...

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Detalles Bibliográficos
Publicado en:Drug Deliv
Autores principales: Hou, Yuzhen, Zhang, Fan, Lan, Jie, Sun, Fengyuan, Li, Jun, Li, Mengshuang, Song, Kaichao, Wu, Xianggen
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407586/
https://ncbi.nlm.nih.gov/pubmed/30822157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2019.1568624
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