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ACAT: A Fast and Powerful p Value Combination Method for Rare-Variant Analysis in Sequencing Studies

Set-based analysis that jointly tests the association of variants in a group has emerged as a popular tool for analyzing rare and low-frequency variants in sequencing studies. The existing set-based tests can suffer significant power loss when only a small proportion of variants are causal, and thei...

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Pubblicato in:Am J Hum Genet
Autori principali: Liu, Yaowu, Chen, Sixing, Li, Zilin, Morrison, Alanna C., Boerwinkle, Eric, Lin, Xihong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407498/
https://ncbi.nlm.nih.gov/pubmed/30849328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.01.002
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