Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure

The hemoglobin β(S) sickle mutation is a textbook case in which natural selection maintains a deleterious mutation at high frequency in the human population. Homozygous individuals for this mutation develop sickle-cell disease, whereas heterozygotes benefit from higher protection against severe mala...

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Gepubliceerd in:Am J Hum Genet
Hoofdauteurs: Laval, Guillaume, Peyrégne, Stéphane, Zidane, Nora, Harmant, Christine, Renaud, François, Patin, Etienne, Prugnolle, Franck, Quintana-Murci, Lluis
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2019
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407493/
https://ncbi.nlm.nih.gov/pubmed/30827499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.02.007
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