Recent Adaptive Acquisition by African Rainforest Hunter-Gatherers of the Late Pleistocene Sickle-Cell Mutation Suggests Past Differences in Malaria Exposure

The hemoglobin β(S) sickle mutation is a textbook case in which natural selection maintains a deleterious mutation at high frequency in the human population. Homozygous individuals for this mutation develop sickle-cell disease, whereas heterozygotes benefit from higher protection against severe mala...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Am J Hum Genet
Hlavní autoři: Laval, Guillaume, Peyrégne, Stéphane, Zidane, Nora, Harmant, Christine, Renaud, François, Patin, Etienne, Prugnolle, Franck, Quintana-Murci, Lluis
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2019
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407493/
https://ncbi.nlm.nih.gov/pubmed/30827499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2019.02.007
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky