Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification

Fibrodysplasia ossificans progressiva (FOP), a congenital heterotopic ossification (HO) syndrome caused by gain-of-function mutations of bone morphogenetic protein (BMP) type I receptor ACVR1, manifests with progressive ossification of skeletal muscles, tendons, ligaments, and joints. HO can occur i...

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Publicado no:Sci Transl Med
Main Authors: Dey, Devaveena, Bagarova, Jana, Hatsell, Sarah J., Armstrong, Kelli A., Huang, Lily, Ermann, Joerg, Vonner, Ashley J., Shen, Yue, Mohedas, Agustin H., Lee, Arthur, Eekhoff, Elisabeth M.W., van Schie, Annelies, Demay, Marie B., Keller, Charles, Wagers, Amy J., Economides, Aris N., Yu, Paul B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407419/
https://ncbi.nlm.nih.gov/pubmed/27881824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aaf1090
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