Nevoid Basal Cell Carcinoma Syndrome: PTCH1 Mutation Profile and Expression of Genes Involved in the Hedgehog Pathway in Argentinian Patients

Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder characterized by multiple basal cell carcinomas (BCC), mainly caused by PTCH1 gene mutations. Our current study aimed to establish (1) PTCH1 germinal and somatic mutational status, (2) component and Hedgehog (HH) pathway...

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Bibliographische Detailangaben
Veröffentlicht in:Cells
Hauptverfasser: Martinez, Maria Florencia, Romano, Maria Vanesa, Martinez, Alfredo Pedro, González, Abel, Muchnik, Carolina, Stengel, Fernando Miguel, Mazzuoccolo, Luis Daniel, Azurmendi, Pablo Javier
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406887/
https://ncbi.nlm.nih.gov/pubmed/30754660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8020144
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