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The Contribution of Pluripotent Stem Cell (PSC)-Based Models to the Study of Fragile X Syndrome (FXS)

Fragile X syndrome (FXS) is the most common heritable form of cognitive impairment. It results from a deficiency in the fragile X mental retardation protein (FMRP) due to a CGG repeat expansion in the 5′-UTR of the X-linked FMR1 gene. When CGGs expand beyond 200 copies, they lead to epigenetic gene...

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Publicat a:Brain Sci
Autors principals: Abu Diab, Manar, Eiges, Rachel
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406836/
https://ncbi.nlm.nih.gov/pubmed/30769941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/brainsci9020042
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