Polyamine Metabolism as a Therapeutic Target in Hedgehog-Driven Basal Cell Carcinoma and Medulloblastoma

Hedgehog (Hh) signaling is a critical developmental regulator and its aberrant activation, due to somatic or germline mutations of genes encoding pathway components, causes Basal Cell Carcinoma (BCC) and medulloblastoma (MB). A growing effort has been devoted at the identification of druggable vulne...

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Dades bibliogràfiques
Publicat a:Cells
Autors principals: Coni, Sonia, Di Magno, Laura, Serrao, Silvia Maria, Kanamori, Yuta, Agostinelli, Enzo, Canettieri, Gianluca
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2019
Matèries:
Review
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406590/
https://ncbi.nlm.nih.gov/pubmed/30754726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8020150
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