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Direct Single-Cell Analysis of Human Polar Bodies and Cleavage-Stage Embryos Reveals No Evidence of the Telomere Theory of Reproductive Ageing in Relation to Aneuploidy Generation

Reproductive ageing in women, particularly after the age of 35, is associated with an exponential increase in the proportion of chromosomally abnormal oocytes produced. Several hypotheses have attempted to explain this observation, including the ‘limited oocyte pool’ hypothesis and the ‘two-hit’ hyp...

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Bibliografiske detaljer
Udgivet i:Cells
Main Authors: Turner, Kara, Lynch, Colleen, Rouse, Hannah, Vasu, Vimal, Griffin, Darren K.
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6406255/
https://ncbi.nlm.nih.gov/pubmed/30781491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells8020163
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