Persistence of Human Immunodeficiency Virus-1 Drug Resistance Mutations in Proviral Deoxyribonucleic Acid After Virologic Failure of Efavirenz-Containing Antiretroviral Regimens

BACKGROUND: Efavirenz (EFV)-based regimens select broad drug resistance to nonnucleoside reverse-transcriptase inhibitors (NNRTIs), limiting the effectiveness of EFV and other NNRTIs. The duration, persistence, and decay of drug resistance mutations (DRMs) in the proviral reservoir is not well defin...

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Detalhes bibliográficos
Publicado no:Open Forum Infect Dis
Main Authors: De La Cruz, Justin, Vardhanbhuti, Saran, Sahoo, Malaya K, Rovner, Robert, Bosch, Ronald J, Manasa, Justen, Katzenstein, David A, Pinsky, Benjamin A
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Major Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405934/
https://ncbi.nlm.nih.gov/pubmed/30863788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz034
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