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Targeting EGFR exon 20 insertion mutations in non-small cell lung cancer

Inframe insertions of three or more base pairs in exon 20 of the epidermal growth factor receptor (EGFR) gene were among the first EGFR mutations to be identified as oncogenic drivers in non-small cell lung cancer (NSCLC). However, unlike the classical EGFR L858R point mutation or exon 19 deletions,...

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Detalhes bibliográficos
Publicado no:Signal Transduct Target Ther
Main Authors: Vyse, Simon, Huang, Paul H.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405763/
https://ncbi.nlm.nih.gov/pubmed/30854234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41392-019-0038-9
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