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CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias
BACKGROUND: The sodium channel, Na(v)1.5, encoded by SCN5A, undergoes developmentally regulated splicing from inclusion of exon 6A in the fetal heart to exon 6B in adults. These mutually exclusive exons differ in 7 amino acids altering the electrophysiological properties of the Na(v)1.5 channel. In...
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| Publicado no: | J Am Heart Assoc |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6404881/ https://ncbi.nlm.nih.gov/pubmed/30371314 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.010393 |
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