Activation of NLRP3 Inflammasome Promotes Foam Cell Formation in Vascular Smooth Muscle Cells and Atherogenesis Via HMGB1

BACKGROUND: This study aimed at investigating whether NLRP3 (the Nod like receptor family, pyrin domain‐containing 3 protein) inflammasome activation induced HMGB1 (high mobility group box‐1 protein) secretion and foam cell formation in human vascular smooth muscle cells (VSMCs) and atherosclerosis...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Wang, Rui, Wu, Weibin, Li, Wen, Huang, Shuichuan, Li, Zilun, Liu, Ruiming, Shan, Zhen, Zhang, Chunxiang, Wang, Shenming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404867/
https://ncbi.nlm.nih.gov/pubmed/30371306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.008596
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