Small molecule inhibits respiratory syncytial virus entry and infection by blocking the interaction of the viral fusion protein with the cell membrane

Antiviral drug development against respiratory syncytial virus (RSV) is urgently needed due to the public health significance of the viral infection. Here, we report the anti-RSV activity of a small molecule, (1S,3R,4R,5R)-3,4-bis{[(E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-1,5-dihydroxycyclohexan...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Tang, Wei, Li, Manmei, Liu, Yujun, Liang, Ning, Yang, Zhu, Zhao, Yanxiang, Wu, Shuai, Lu, Sangwei, Li, Yaolan, Liu, Fenyong
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2019
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404555/
https://ncbi.nlm.nih.gov/pubmed/30571312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201800579R
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