Ufbp1 promotes plasma cell development and ER expansion by modulating distinct branches of UPR

The IRE1α/XBP1 branch of unfolded protein response (UPR) pathway has a critical function in endoplasmic reticulum (ER) expansion in plasma cells via unknown mechanisms; interestingly, another UPR branch, PERK, is suppressed during plasma cell development. Here we show that Ufbp1, a target and cofact...

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Pubblicato in:Nat Commun
Autori principali: Zhu, Huabin, Bhatt, Brinda, Sivaprakasam, Sathish, Cai, Yafei, Liu, Siyang, Kodeboyina, Sai Karthik, Patel, Nikhil, Savage, Natasha M., Sharma, Ashok, Kaufman, Randal J., Li, Honglin, Singh, Nagendra
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403283/
https://ncbi.nlm.nih.gov/pubmed/30842412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08908-5
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