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Pyruvate-depleting conditions induce biofilm dispersion and enhance the efficacy of antibiotics in killing biofilms in vitro and in vivo

The formation of biofilms is a developmental process initiated by planktonic cells transitioning to the surface, which comes full circle when cells disperse from the biofilm and transition to the planktonic mode of growth. Considering that pyruvate has been previously demonstrated to be required for...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Goodwine, James, Gil, Joel, Doiron, Amber, Valdes, Jose, Solis, Michael, Higa, Alex, Davis, Stephen, Sauer, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403282/
https://ncbi.nlm.nih.gov/pubmed/30842579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40378-z
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