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Efficient editing DNA regions with high sequence identity in actinomycetal genomes by a CRISPR-Cas9 system
Actinobacteria able to produce varieties of bioactive natural products have been long appreciated by the field of drug discovery and development. Recently, a few of CRISPR/Cas9 systems bearing different types of replicons (pSG5 and pIJ101) were developed to efficiently edit their genomes. Despite wi...
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| Udgivet i: | Synth Syst Biotechnol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
KeAi Publishing
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6403111/ https://ncbi.nlm.nih.gov/pubmed/30891508 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.synbio.2019.02.004 |
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