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Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia

D-serine, an endogenous coagonist of N-methyl-d-aspartate receptors (NMDARs) at the glycine binding site, is synthesized by serine racemase (SR) through conversion of L-serine. Dysregulation of SR/D-serine and Disrupted-In-Schizophrenia-1 (DISC1) contributes to the pathogenesis of schizophrenia at c...

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Detalhes bibliográficos
Publicado no:Neurosci Lett
Main Authors: Jacobi, Ariel A., Halawani, Sarah, Lynch, David R., Lin, Hong
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6402792/
https://ncbi.nlm.nih.gov/pubmed/30391323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2018.10.055
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