Phase I Study Combining the Aurora Kinase A Inhibitor Alisertib with mFOLFOX in Gastrointestinal Cancer

Overexpression and cellular miss-localization of aurora kinase A (AURKA) in gastrointestinal cancers results in chromosomal instability, activation of multiple oncogenic pathways, and inhibition of pro-apoptotic signaling. Inhibition of AURKA causes mitotic delays, severe chromosome congression, and...

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Publicat a:Invest New Drugs
Autors principals: Goff, Laura W., Azad, Nilofer S., Stein, Stacey, Whisenant, Jennifer G., Koyama, Tatsuki, Vaishampayan, Ulka, Hochster, Howard, Connolly, Roisin, Weise, Amy, LoRusso, Patricia M., Salaria, Safia N., El-Rifai, Wael, Berlin, Jordan D.
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6401337/
https://ncbi.nlm.nih.gov/pubmed/30191522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10637-018-0663-0
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