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The use of technical replication for detection of low-level somatic mutations in next-generation sequencing
Accurate genome-wide detection of somatic mutations with low variant allele frequency (VAF, <1%) has proven difficult, for which generalized, scalable methods are lacking. Herein, we describe a new computational method, called RePlow, that we developed to detect low-VAF somatic mutations based on...
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| Publicado no: | Nat Commun |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6400950/ https://ncbi.nlm.nih.gov/pubmed/30837471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09026-y |
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