FTO-Dependent m6A Regulates Cardiac Function During Remodeling and Repair

BACKGROUND: Despite its functional importance in various fundamental bioprocesses, the studies of N6-methyladenosine (m6A) in the heart are lacking. Here we show that, fat mass and obesity-associated (FTO), an m6A demethylase, plays a critical role in cardiac contractile function during homeostasis,...

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Publicado en:Circulation
Autores principales: Mathiyalagan, Prabhu, Adamiak, Marta, Mayourian, Joshua, Sassi, Yassine, Liang, Yaxuan, Agarwal, Neha, Jha, Divya, Zhang, Shihong, Kohlbrenner, Erik, Chepurko, Elena, Chen, Jiqiu, Trivieri, Maria G., Singh, Rajvir, Bouchareb, Rihab, Fish, Kenneth, Ishikawa, Kiyotake, Lebeche, Djamel, Hajjar, Roger J, Sahoo, Susmita
Formato: Artigo
Lenguaje:Inglês
Publicado: 2019
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400591/
https://ncbi.nlm.nih.gov/pubmed/29997116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.033794
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