A new highly sensitive real-time quantitative-PCR method for detection of BCR-ABL1 to monitor minimal residual disease in chronic myeloid leukemia after discontinuation of imatinib

Tyrosine kinase inhibitors (TKIs) targeting the BCR-ABL1 fusion protein, encoded by the Philadelphia chromosome, have drastically improved the outcomes for patients with chronic myeloid leukemia (CML). Although several real-time quantitative polymerase chain reaction (RQ-PCR) kits for the detection...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS One
Autori principali: Kitamura, Hiroaki, Tabe, Yoko, Ai, Tomohiko, Tsuchiya, Koji, Yuri, Maiko, Misawa, Shigeki, Horii, Takashi, Kawaguchi, Atsushi, Ohsaka, Akimichi, Kimura, Shinya
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2019
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400442/
https://ncbi.nlm.nih.gov/pubmed/30835732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0207170
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