Effect of Multidrug-Resistant 1 (MDR1) and CYP3A4*1B Polymorphisms on Cyclosporine-Based Immunosuppressive Therapy in Renal Transplant Patients

BACKGROUND: Immunosuppressive drugs such as cyclosporine A (CsA) are characterized by a narrow therapeutic range and high interindividual pharmacokinetic variations. Therefore, the effective monitoring of drug serum level is crucial for successful therapy. This variability can be caused by polymorph...

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Vydáno v:Ann Transplant
Hlavní autoři: Kotowski, Maciej J., Bogacz, Anna, Bartkowiak-Wieczorek, Joanna, Tejchman, Karol, Dziewanowski, Krzysztof, Ostrowski, Marek, Czerny, Bogusław, Grześkowiak, Edmund, Machaliński, Bogusław, Sieńko, Jerzy
Médium: Artigo
Jazyk:Inglês
Vydáno: International Scientific Literature, Inc. 2019
Témata:
Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6400024/
https://ncbi.nlm.nih.gov/pubmed/30799432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/AOT.914683
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