Exceptional response and multisystem autoimmune-like toxicities associated with the same T cell clone in a patient with uveal melanoma treated with immune checkpoint inhibitors

Balancing the potential for durable remissions with autoimmune-like toxicities is a key clinical challenge in the use of immune checkpoint inhibitors (ICI). Certain toxicities are associated with an increased response rate; however, the molecular underpinnings of this association are poorly understo...

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Библиографические подробности
Опубликовано в: :J Immunother Cancer
Главные авторы: Rapisuwon, Suthee, Izar, Benjamin, Batenchuk, Cory, Avila, Alexandre, Mei, Shaolin, Sorger, Peter, Parks, Jerry M., Cooper, Sarah J., Wagner, David, Zeck, Jay C., Charabaty, Aline J., Atkins, Michael B.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Case Report
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399858/
https://ncbi.nlm.nih.gov/pubmed/30832716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0533-0
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