Dysfunctional high-density lipoprotein activates toll-like receptors via serum amyloid A in vascular smooth muscle cells

Serum amyloid A (SAA) is an uremic toxin and acute phase protein. It accumulates under inflammatory conditions associated with high cardiovascular morbidity and mortality in patients with sepsis or end-stage renal disease (ESRD). SAA is an apolipoprotein of the high-density lipoprotein (HDL). SAA ac...

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Publicado no:Sci Rep
Main Authors: Schuchardt, Mirjam, Prüfer, Nicole, Tu, Yuexing, Herrmann, Jaqueline, Hu, Xiu-Ping, Chebli, Sarah, Dahlke, Katja, Zidek, Walter, van der Giet, Markus, Tölle, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399289/
https://ncbi.nlm.nih.gov/pubmed/30833653
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39846-3
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