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High-resolution structure determination of sub-100 kDa complexes using conventional cryo-EM

Determining high-resolution structures of biological macromolecules amassing less than 100 kilodaltons (kDa) has been a longstanding goal of the cryo-electron microscopy (cryo-EM) community. While the Volta phase plate has enabled visualization of specimens in this size range, this instrumentation i...

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Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Herzik, Mark A., Wu, Mengyu, Lander, Gabriel C.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6399227/
https://ncbi.nlm.nih.gov/pubmed/30833564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08991-8
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