High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds

Bone morphogenetic protein (BMP) signaling is critical in renal development and disease. In animal models of chronic kidney disease (CKD), re-activation of BMP signaling is reported to be protective by promoting renal repair and regeneration. Clinical use of recombinant BMPs, however, requires harmf...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bradford, Shayna T. J., Ranghini, Egon J., Grimley, Edward, Lee, Pil H., Dressler, Gregory R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398139/
https://ncbi.nlm.nih.gov/pubmed/30602563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006817
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