Disruption of peroxisome proliferator–activated receptor γ coactivator (PGC)-1α reverts key features of the neoplastic phenotype of glioma cells

The peroxisome proliferator–activated receptor γ coactivator (PGC)-1α is a master regulator of mitochondrial biogenesis and controls metabolism by coordinating transcriptional events. Here, we interrogated whether PGC-1α is involved in tumor growth and the metabolic flexibility of glioblastoma cells...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Bruns, Ines, Sauer, Benedikt, Burger, Michael C., Eriksson, Jule, Hofmann, Ute, Braun, Yannick, Harter, Patrick N., Luger, Anna-Luisa, Ronellenfitsch, Michael W., Steinbach, Joachim P., Rieger, Johannes
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2019
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6398126/
https://ncbi.nlm.nih.gov/pubmed/30578297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006993
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